Max is correct.
Majority of Retro Builders either have the Software/Firmware gene (Doug), or the PC board layout/stuff components/build.IF you look at the swath of "retro" 8-bit projects, they run the gambit from exact replicas: AltairKit 8080 and 680 by Grant Stockly); to updates: Lee Bird's Heathkit H-8 update or Spare Time Gizmo's Cosmac ELF 2K.
Everyone of these projects struggled with the enclosure / packaging due to 2012 fabrication costs. In taking with those project leaders, it is an after thought or a real struggle.
The "typical" solution is they don't develop one OR retro-fit into original 1970s / 1980s cases.I am not worried about 170mm x 170mm space of Mimi-ITX, since you can easily add a PC-104 (well documented for 8-bit and 16-bit) expansion connector for a second stack card or option (e.g. CF Card, memory, CPU module)
The mini-ITX allows for the height above board, since they planned for large fan/heat sink assemblies.
I don't see a super-charged 8-bit processor with major heat issues.I'll close with, Sometimes the worst situation for a design is not having enough constraints.
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